Hey! While I'm away, could you please do the dishes? Also, try not to make a huge mess in the living room while playing video games. I promise to make us a delicious homemade pizza on Sunday night when I return. Just do your best to keep the cat entertained!

Do is generally used for chores, tasks, and general activities (like do the dishes or do your best).

Make is used when we create, build, or produce something that wasn't there before (like make a mess or make a pizza).