The green potion had an unexpected effect on the laboratory mice. I strongly advise my assistant to double-check the cages tonight. If the door hinges are loose, the mice will escape and conquer the city!

Effect is a noun meaning a result, while affect is usually a verb meaning to influence.

Advise is a verb meaning to give guidance, whereas advice is a noun.

Loose is an adjective meaning not tight or not securely attached, while lose is a verb meaning to misplace something or fail to win.